Assistant Project Scientist - Modeling Genetic Risk for Diabetes Using Pluripotent Stem Cells
University of California San Diego
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Post Date: Jan 24, 2018
Job Type: Full time
Start Date: - n/a -
Salary: - n/a -
Location: US - California - San Diego
Job Reference: - n/a -
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THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (UCSD), DEPARTMENT OF PEDIATRICS ( is committed to academic excellence and diversity within the faculty, staff, and student body and seek applicants for a joint project scientist position with Dr. Maike Sander and Dr. Kyle Gaulton to conduct integrative research in genomics, genetics and cell biology investigating the functional role of diabetes-associated genetic variants in pancreatic beta cells.


The position involves joining a large NIH-funded multi-disciplinary team broadly focused on identifying and functionally characterizing regulatory variants influencing type 1 and type 2 diabetes risk. The aims of this project are to (1) combine large-scale human genetic and epigenomic data to identify regulatory variants underlying diabetes risk; (2) employ CRISPR/Cas9-mediated gene editing of risk variants and regions in human pluripotent stem cells (hPSCs) and differentiate hPSCs into pancreatic islet beta cells; (3) generate and analyze high-throughput epigenome, transcriptome, and phenotype data; (4) establish genotype-phenotype relationships at the molecular and physiological level. The expectation is that the candidate will plan, conduct, and analyze experiments, supervise technicians, and coordinate collaborative efforts between laboratories.


Our research is highly collaborative and involves a consortium of several laboratories. This research team is equipped with next-generation sequencing technology, state-of-the-art computational resources, stem cell culture facilities and islet cell phenotyping equipment. We are seeking a project scientist to conduct multi-disciplinary research in diabetes genetics and disease modeling using pluripotent stem cells.


Candidates must have a PhD and experience in genome engineering, hPSC culture, islet cell biology, statistical genetics, and epigenomics, and experience in conducting integrative, cutting-edge research within multi-disciplinary teams. A background in working with pluripotent stem cells is required. Strong organizational and communication skills are required, and the candidate is expected to write manuscripts and help with grant writing.


Appointment will be at Assistant Project Scientist. Salary is commensurate with qualifications and based on University of California pay scales.


Applications must be submitted through the University of California San Diego's Academic Personnel RECRUIT system at:


References (contact information or letter of recommendation) may be requested from all finalists.


The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to gender, race, color, religion, sex, national origin, disability, age or protected veteran status.

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