Postdoc Position in Cellular Modeling of Diabetes Risk Variants Using Pluripotent Stem Cells
University of California San Diego
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Post Date: Jan 24, 2018
Job Type: Full time
Start Date: - n/a -
Salary: - n/a -
Location: US - California
Job Reference: - n/a -
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A postdoc position is available jointly with Dr. Maike Sander and Dr. Kyle Gaulton at the University of California, San Diego to conduct integrative research in genomics, genetics and cell biology investigating the functional role of diabetes-associated genetic variants in pancreatic beta cells. The position involves joining a large NIH-funded multi-disciplinary team broadly focused on identifying and functionally characterizing regulatory variants influencing type 1 and type 2 diabetes risk.


The aims of this project are to (1) combine large-scale human genetic and epigenomic data to identify regulatory variants underlying diabetes risk; (2) employ CRISPR/Cas9-mediated gene editing of risk variants and regions in human pluripotent stem cells (hPSCs) and differentiate hPSCs into pancreatic islet beta cells; (3) generate and analyze high-throughput epigenome, transcriptome, and phenotype data; (4) establish genotype-phenotype relationships at the molecular and physiological level. The expectation is that the candidate will plan, conduct, and analyze experiments, supervise technicians, and coordinate collaborative efforts between laboratories.


The ideal candidate will have experience in genome engineering, hPSC culture, islet cell biology, statistical genetics, and epigenomics, and seeking experience in conducting integrative, cutting-edge research within multi-disciplinary teams. Strong organizational and communication skills are required, and the candidate is expected to write manuscripts and help with grant writing.


Our research is highly collaborative and involves a consortium of several laboratories. This research team is equipped with next-generation sequencing technology, state-of-the-art computational resources, stem cell culture facilities and islet cell phenotyping equipment.


Salary will be commensurate with qualifications and experience and based on UC San Diego salary scales.


To apply: Applicants should send a detailed curriculum vitae, a list of publications, and a statement of research interests to Maike Sander, MD, at and Kyle Gaulton, PhD, at

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